Hatazawa J, Yamaguchi T, Ito M, Yamaura H, Matsuzawa T
J Am Geriatr Soc. 1984 May;32(5):370-4. doi: 10.1111/j.1532-5415.1984.tb02042.x.
Atrophy of brain matter in hypertensive and normotensive subjects was studied by quantitative measurements of brain volume and cranial cavity volume using x-ray computed tomography. The 123 normotensive subjects ranged in age from 20 to 79 years and were divided into six ten-year age groups. The 67 hypertensive subjects ranged in age from 40 to 83 years and were divided into four age groups. Values of the brain volume index ( BVI ), the ratio of brain matter volume to cranial cavity volume, for hypertensives and normotensives in the same age groups were compared. Mean BVI values were significantly lower in hypertensives in the fifth (P less than 0.01), sixth (P less than 0.01), seventh (P less than 0.05) and eighth and ninth decades of life (P less than 0.001). Systemic hypertension, which may induce various diseases in the elderly, had a striking effect on atrophic changes of brain matter in elderly subjects.
通过使用X射线计算机断层扫描对脑容量和颅腔容量进行定量测量，研究了高血压患者和血压正常者的脑实质萎缩情况。123名血压正常者年龄在20至79岁之间，被分为六个十岁年龄组。67名高血压患者年龄在40至83岁之间，被分为四个年龄组。比较了同一年龄组高血压患者和血压正常者的脑容量指数（BVI），即脑实质体积与颅腔体积的比值。在第五个十年（P<0.01）、第六个十年（P<0.01）、第七个十年（P<0.05）以及第八和第九个十年（P<0.001）中，高血压患者的平均BVI值显著较低。可能诱发老年人各种疾病的全身性高血压，对老年受试者脑实质的萎缩性变化有显著影响。
