McClurkin J W, Marrocco R T
J Physiol. 1984 Mar;348:135-52. doi: 10.1113/jphysiol.1984.sp015103.
The response of monkey lateral geniculate nucleus (l.g.n.) cells to flashing spots, annuli, and drifting sine-wave gratings were recorded with tungsten micro-electrodes. These stimuli were presented (a) monocularly, through an aperture in the centre of a radial grating, or (b) dichoptically, in which the spots or drifting gratings were presented to the dominant eye's receptive field, while the centre of the radial grating was positioned on the corresponding retinal location of the other eye. Movement of the radial grating produced changes in the l.g.n. cell responses evoked by the spots and sine-wave gratings. These changes were reversed by cryogenic blockade of the striate cortex. Therefore, radial grating movement altered the responses of l.g.n. cells by activating the corticogeniculate (c.g.) pathway. In about half of all cells, radial grating-induced alterations of centre, or surround, or both responses to spots and annuli were produced. By adopting a simple spatial filtering model of the centre and surround mechanisms, it was possible to predict how these alterations in centre/surround balance would affect the cell's responses to sine-wave gratings. Alterations were observed in the peak and band width of the spatial and/or temporal tuning curves. The radial gratings did not alter the spatial summation properties of cells. Minor alterations in the spectral neutral points of chromatically opponent neurones were occasionally found. These results are interpreted as support for the view that spatial and temporal tuning are dynamic properties of some l.g.n. neurones by virtue of descending input from the visual cortex.
用钨微电极记录了猴外侧膝状体（l.g.n.）细胞对闪烁光斑、光环以及漂移正弦波光栅的反应。这些刺激呈现方式如下：（a）单眼呈现，通过径向光栅中心的一个小孔；或者（b）双眼分别呈现，即光斑或漂移光栅呈现给优势眼的感受野，而径向光栅的中心位于另一只眼相应的视网膜位置上。径向光栅的移动改变了光斑和正弦波光栅诱发的外侧膝状体细胞反应。这些变化可通过纹状皮层的低温阻断而逆转。因此，径向光栅的移动通过激活皮质膝状体（c.g.）通路改变了外侧膝状体细胞的反应。在所有细胞中，约有一半细胞对光斑和光环的中心或周边反应，或两者反应，受到径向光栅诱导的改变。通过采用中心和周边机制的简单空间滤波模型，可以预测中心/周边平衡的这些改变将如何影响细胞对正弦波光栅的反应。观察到空间和/或时间调谐曲线的峰值和带宽发生了改变。径向光栅没有改变细胞的空间总和特性。偶尔会发现色拮抗神经元的光谱中性点有轻微改变。这些结果被解释为支持这样一种观点，即空间和时间调谐是一些外侧膝状体神经元的动态特性，这得益于来自视觉皮层的下行输入。
