Navas-Palacios J J, Usera-Sárraga G, Gil-Martin R, Gutierrez-Millet V
J Toxicol Environ Health. 1984;13(1):1-18. doi: 10.1080/15287398409530477.
In May 1981, a massive intoxication of people who had ingested adulterated cooking oil took place in Madrid and nearby provinces. Although the patients presented, in the first phase of the disease, with acute respiratory illness, later on thromboembolic complications, severe neuromuscular involvement, and scleroderma-like cutaneous lesions appeared. Kidneys were apparently spared; however, 4 out of 842 admitted patients developed glomerulonephritis; kidney biopsies revealed glomerular, vascular, tubular, and interstitial changes. Cases 1 and 3 had diffuse proliferative endocapillary glomerulonephritis; case 2 had diffuse membranoproliferative glomerulonephritis; and case 4 had diffuse extracapillary glomerulonephritis. Three cases had vascular lesions characterized by degenerative and proliferative endothelial changes, intimal foamy macrophages, and partial or complete obliteration of the vascular lumen by concentric myxoid fibrosis. There were signs of necrosis of tubular epithelium along with edema and lymphocytic and eosinophilic interstitial infiltration. Two out of 22 autopsies had segmentary glomerulonephritis, and 17 out of 22 autopsies showed renal vascular lesions.
1981年5月，马德里及其周边省份发生了大规模食用油掺假致人群中毒事件。虽然患者在疾病的第一阶段表现为急性呼吸道疾病，但随后出现了血栓栓塞并发症、严重的神经肌肉受累以及硬皮病样皮肤病变。肾脏显然未受影响；然而，在842名入院患者中，有4人发展为肾小球肾炎；肾脏活检显示肾小球、血管、肾小管和间质均有变化。病例1和病例3为弥漫性增生性毛细血管内增生性肾小球肾炎；病例2为弥漫性膜增生性肾小球肾炎；病例4为弥漫性毛细血管外增生性肾小球肾炎。3例出现血管病变，其特征为内皮细胞变性和增生、内膜泡沫状巨噬细胞以及同心性黏液样纤维化导致血管腔部分或完全闭塞。有肾小管上皮坏死的迹象，伴有水肿以及淋巴细胞和嗜酸性粒细胞间质浸润。22例尸检中有2例出现节段性肾小球肾炎，22例尸检中有17例显示肾血管病变。
