Cherian T, Joseph A, John T J
J Trop Med Hyg. 1984 Feb;87(1):27-31.
During a measles epidemic (December 1979-March 1980) in two adjacent villages in Tamil Nadu, 78 of 143 under-fives were affected, eight of whom died, giving an attack rate of 54% and case-fatality rate of 10%. Seven months later 72 children (41 with measles, seven with history of measles in prior epidemics and 24 with no history of measles) were bled to measure measles virus haemagglutination-inhibition antibody. Of the 48 with measles history, 46 had measurable antibody. Surprisingly, of the 24 without a history, 16 had measurable antibody indicating the frequency of subclinical measles during epidemics. The geometric mean antibody titre was lower in infants with measles than in older children (P less than 0.05). The mean titre was lower in those with subclinical measles than in those with clinical measles (P less than 0.01).
在泰米尔纳德邦两个相邻村庄的麻疹流行期间（1979年12月至1980年3月），143名五岁以下儿童中有78名受到感染，其中8名死亡，发病率为54%，病死率为10%。七个月后，对72名儿童（41名患麻疹，7名在先前流行中有麻疹病史，24名无麻疹病史）进行采血以检测麻疹病毒血凝抑制抗体。在有麻疹病史的48名儿童中，46名有可检测到的抗体。令人惊讶的是，在无病史的24名儿童中，16名有可检测到的抗体，这表明流行期间亚临床麻疹的发生率。患麻疹婴儿的几何平均抗体滴度低于大龄儿童（P<0.05）。亚临床麻疹患儿的平均滴度低于临床麻疹患儿（P<0.01）。
