Wright G L, McCumbee W D
Life Sci. 1984 Apr 16;34(16):1521-8. doi: 10.1016/0024-3205(84)90606-4.
A substance has been obtained from the blood of spontaneously hypertensive rats which produces a hypertensive elevation of the blood pressure in normotensive rats. The substance is dialyzable and is associated with the erythrocyte membrane. It appears to be relatively long-lived in its effect on arterial pressure. The erythrocyte fractions that exhibit pressor activity also stimulate the in vitro uptake of calcium by aortas obtained from normotensive animals. This suggests that the hypertensive factor or related substances may influence the calcium metabolism of vascular tissue.
已从自发性高血压大鼠的血液中获得一种物质，该物质可使正常血压大鼠的血压升高至高血压水平。这种物质可透析，且与红细胞膜有关。它对动脉血压的影响似乎持续时间较长。表现出升压活性的红细胞组分也能刺激从正常血压动物获取的主动脉在体外摄取钙。这表明高血压因子或相关物质可能会影响血管组织的钙代谢。
