在用肿瘤启动子12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯处理的腺病毒感染的HeLa细胞中病毒转录的加速起始。
Accelerated onset of viral transcription in adenovirus-infected HeLa cells treated with the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.
作者信息
Carter T H, Milovanovic Z Z, Babiss L E, Fisher P B
出版信息
Mol Cell Biol. 1984 Mar;4(3):563-6. doi: 10.1128/mcb.4.3.563-566.1984.
Abstract
When adenovirus type 5-infected HeLa cells were exposed to the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate, short pulse-labeling with [3H]uridine in vivo and [3H]UTP incorporation by isolated nuclei in vitro were both consistent with a decreased latent period before initiation by RNA polymerase at early viral promoters. Acceleration was not dependent upon concurrent protein synthesis and could not be attributed to rapid entry of virus into the cell nucleus. 12-O-tetradecanoyl-phorbol-13-acetate suppressed the transcription-delay phenotype of the E1a mutant, hr1, without restoring its ability to replicate.
摘要
当用5型腺病毒感染的HeLa细胞暴露于肿瘤启动子12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯时，体内用[3H]尿苷进行的短脉冲标记以及体外分离细胞核中[3H]UTP的掺入，均与早期病毒启动子处RNA聚合酶起始前潜伏期缩短一致。加速并不依赖于同时进行的蛋白质合成，也不能归因于病毒快速进入细胞核。12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯抑制了E1a突变体hr1的转录延迟表型，但未恢复其复制能力。
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本文引用的文献
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