[Circadian rhythms in total serum proteins, IgM and C3 component of complement in 40 adult males apparently in good health].

Circadian changes of total proteins erythrocyte sedimentation rate, IgA, IgG, IgM and 12 others blood compounds were documented in 40, 40-60 years old, hospitalized males without any inflammatory or hepatic disease. These patients were synchronized by diurnal activity and nocturnal rest, and each of them was submitted to 5 samples during a 24 hours scale (07.00, 13.00, 19.00, 01.00 and 07.00). We only detected C3, IgM and total proteins significant circadian rhythms (peak time in the diurnal period). When these data were analysed by mean-Cosinor, they revealed three groups of subjects: 16 patients with an acrophase at 17.00 +/- 3.00, 8 with an acrophase at 06.00 +/- 3.00 and 16 (third/group) with large differences in the acrophase values. Such heterogenous results are discussed.