Gomez S, Love S
Q J Exp Physiol. 1984 Jan;69(1):197-205. doi: 10.1113/expphysiol.1984.sp002780.
The effects of X-irradiation on nerve regeneration were examined in adult mice. The right sciatic nerve was crushed focally and 3 d later the hind limb was exposed to 20 Gy X-rays. Compound muscle action potentials (m.a.p.s) were recorded in vivo from the posterior crural muscles. Stimulation of the sciatic nerve proximal to the crush injury evoked m.a.p.s of low amplitude with marked temporal dispersion. Stimulation at 20 or 50 Hz resulted in almost immediate intermittent failure of the longer latency m.a.p.s. In vitro physiological examination showed X-irradiation to have no effect on the timing of reinnervation. However, the latency of evoked end-plate potentials was prolonged and, on repetitive nerve stimulation, increased markedly until failure occurred. Nerves which regenerated after X-irradiation showed impaired conduction, particularly of trains of impulses.
在成年小鼠中研究了X射线照射对神经再生的影响。右侧坐骨神经进行局部挤压，3天后后肢接受20 Gy的X射线照射。在体记录小腿后群肌肉的复合肌肉动作电位（m.a.p.s）。在挤压损伤近端刺激坐骨神经可诱发低振幅且伴有明显时间离散的m.a.p.s。以20或50 Hz频率刺激时，潜伏期较长的m.a.p.s几乎立即出现间歇性衰减。体外生理学检查显示，X射线照射对神经再支配的时间没有影响。然而，诱发终板电位的潜伏期延长，并且在重复神经刺激时显著增加直至衰减发生。X射线照射后再生的神经表现出传导受损，尤其是冲动序列的传导。
