Archambeau J O, Ines A, Fajardo L F
Radiat Res. 1984 Apr;98(1):37-51.
An acute single X-ray exposure of 2300 R produces in swine skin a moist reaction (ulceration) that appears at 17 days, heals by 32 days, and may break down again between 42 and 70 days. Initial studies quantified the epidermal population density changes during this 70-day period. This study was designed to quantify the density changes occurring in the endothelial cell population of the dermal microvasculature. While the basal population decreases to a nadir of 10% control by 24 days, the endothelial population remains at control levels. Beyond 24 days, the endothelial cell density decreases abruptly to 50% as the epidermal cell density returns to control levels and overshoots by 20% at 32 days. Subsequently, both populations decrease to zero by 57 days. Endothelial cell loss parallels a similar decrease in vascular lumen density. These findings indicate that the initial moist reaction results from a radiation-induced loss of epidermal cells, while the second reaction results from the loss of dermal microvasculature.
单次急性2300伦琴的X射线照射会使猪的皮肤产生湿性反应（溃疡），该反应在17天时出现，32天时愈合，并且可能在42至70天之间再次破溃。最初的研究对这70天期间表皮细胞群体密度的变化进行了量化。本研究旨在量化真皮微血管内皮细胞群体中发生的密度变化。虽然基底细胞群体在24天时减少至对照水平的最低点10%，但内皮细胞群体仍保持在对照水平。24天之后，随着表皮细胞密度恢复到对照水平并在32天时超过对照水平20%，内皮细胞密度突然降至50%。随后，两个细胞群体在57天时均降至零。内皮细胞的损失与血管腔密度的类似降低情况平行。这些发现表明，最初的湿性反应是由辐射诱导的表皮细胞损失导致的，而第二次反应则是由真皮微血管的损失引起的。
