Ishikawa H, Ohno O, Hirohata K
Rheumatol Int. 1984;4(1):1-8. doi: 10.1007/BF00683876.
The cellular characteristics of the rheumatoid synovial-bone junction (SBJ) were examined in the electron microscope. Large numbers of mononuclear inflammatory cells along the bone suggested the advance of the rheumatoid inflammatory lesion into bone tissue. The SBJ contained macrophage-rich and osteoclast-rich areas. The presence of the macrophage as a predominant cell type and the marked collagenolysis of the eroded bone matrix suggested that collagenase released by macrophages was responsible for a major portion of the bone erosion. The observation of osteoclasts with ruffled borders, containing free bone crystals in close contact with the bone, indicated that these osteoclasts were stimulated by the rheumatoid synovium. It seems likely that articular bone resorption depends upon the local host response to the macrophage and osteoclast in the rheumatoid joint.
利用电子显微镜对类风湿性滑膜-骨连接处（SBJ）的细胞特征进行了检查。沿骨骼存在大量单核炎性细胞，提示类风湿性炎性病变已进展至骨组织。SBJ包含富含巨噬细胞和富含破骨细胞的区域。巨噬细胞作为主要细胞类型的存在以及侵蚀骨基质明显的胶原溶解表明，巨噬细胞释放的胶原酶是骨侵蚀的主要原因。观察到具有皱褶边缘、含有与骨紧密接触的游离骨晶体的破骨细胞，表明这些破骨细胞受到类风湿性滑膜的刺激。关节骨吸收似乎取决于局部宿主对类风湿关节中巨噬细胞和破骨细胞的反应。
