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风湿性组织破坏中的多形核粒细胞。VI. 类风湿性关节炎患者半月板中多形核粒细胞的存在情况。

Polymorphonuclear granulocytes in rheumatic tissue destruction. VI. The occurrence of PMNs in menisci of patients with rheumatoid arthritis.

作者信息

Mohr W, Pelster B, Wessinghage D

出版信息

Rheumatol Int. 1984;5(1):39-44. doi: 10.1007/BF00541364.

DOI:10.1007/BF00541364
PMID:6084867
Abstract

The meniscal surfaces from patients with and without inflammatory joint diseases were investigated for the presence of superficially located polymorphonuclear granulocytes (PMNs). In histochemically stained tissue sections as well as in electron microscopic investigations on previously paraffin-embedded menisci, PMNs were observed in cases with inflammatory rheumatoid joint diseases. The inflammatory cells were located in fibrin adhering to the meniscal surface and in the fibrous meniscal tissue just beneath the fibrin. From these observations it is concluded that PMNs in the inflammatory synovial fluid may gain access to the fibrous structures of the joint, thus participating in tissue destruction, as has been assumed from in vitro investigations by other authors.

摘要

对患有和未患有炎性关节疾病患者的半月板表面进行研究,以检测是否存在浅表定位的多形核粒细胞(PMN)。在组织化学染色的组织切片以及对先前石蜡包埋半月板的电子显微镜检查中,在患有炎性类风湿性关节疾病的病例中观察到了PMN。炎性细胞位于附着在半月板表面的纤维蛋白中以及纤维蛋白下方的半月板纤维组织中。从这些观察结果可以得出结论,炎性滑液中的PMN可能进入关节的纤维结构,从而参与组织破坏,正如其他作者的体外研究所推测的那样。

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本文引用的文献

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Arthritis Rheum. 1983 Apr;26(4):472-8. doi: 10.1002/art.1780260404.
5
An electron microscopic study of the synovial-bone junction in rheumatoid arthritis.类风湿关节炎滑膜-骨连接处的电子显微镜研究
Rheumatol Int. 1984;4(1):1-8. doi: 10.1007/BF00683876.
6
Mast cells at sites of cartilage erosion in the rheumatoid joint.类风湿性关节炎关节软骨侵蚀部位的肥大细胞。
Ann Rheum Dis. 1984 Feb;43(1):76-9. doi: 10.1136/ard.43.1.76.
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Synovial protease/inhibitor ratios in erosive and nonerosive arthropathies.侵蚀性和非侵蚀性关节病中的滑膜蛋白酶/抑制剂比率。
Ann Rheum Dis. 1984 Feb;43(1):50-5. doi: 10.1136/ard.43.1.50.
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Interaction of polymorphonuclear leukocytes with immune complexes trapped in rheumatoid articular cartilage.多形核白细胞与类风湿性关节软骨中捕获的免疫复合物的相互作用。
Arthritis Rheum. 1983 Dec;26(12):1434-41. doi: 10.1002/art.1780261204.
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Proliferative diseases.增殖性疾病
Am J Med. 1981 Jun;70(6):1231-5. doi: 10.1016/0002-9343(81)90832-9.
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Factors involved in cartilage injury.软骨损伤所涉及的因素。
J Rheumatol Suppl. 1983 Dec;11:13-25.