Kodner A S, Orlov R S
Kardiologiia. 1978 Apr;18(4):123-7.
The contraction of smooth muscle cells in response to the effect of catecholamines and potassium chloride was studied in experiments on isolated ring segments of the rabbit aorta under normal conditions and in experimental cholesterol atherosclerosis at its early developmental stages. It was found that at the early stages of atherosclerosis development the character of the contractile reactions was marked by changes which may be considered from the standpoint of disorder in the ion mechanisms of the interrelationships of sodium and calcium both on the membrane and within the smooth muscle cell, and from the standpoint of increased reactivity of chemically sensitive calcium channels of the membrane. The cause of these changes may be the accumulation of cholesterol, lipoproteins and acid mucopolysaccharides in the vascular wall at the early stages of atherosclerosis development.
在正常条件下以及实验性胆固醇动脉粥样硬化早期发展阶段，对兔主动脉离体环段进行实验，研究了平滑肌细胞对儿茶酚胺和氯化钾作用的收缩情况。结果发现，在动脉粥样硬化发展的早期阶段，收缩反应的特征表现出变化，这些变化可以从膜上以及平滑肌细胞内钠和钙相互关系的离子机制紊乱的角度来考虑，也可以从膜化学敏感钙通道反应性增加的角度来考虑。这些变化的原因可能是动脉粥样硬化发展早期血管壁中胆固醇、脂蛋白和酸性粘多糖的积累。
