Beliaev B S, Sirota L A, Minsker E I, Panteleeva G P, Tsutsul'kovskaia M Ia
Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(3):401-6.
To help individual prediction of the therapy efficacy, the authors elaborated a new method for analyzing the response of the clinical and pharmacokinetic parameters to the pre-treatment administration of the test dose of a psychotropic drug. The above approach was employed in a multicentre clinical-pharmacokinetic study of leponex ( clozapin ) which involved ten research centers from six countries and a total of 136 patients. On the basis of the clinical and pharmacokinetic parameters, a cumulative index was obtained and its prediction potentialities were established. The prognostic assessment of the affectiveness obtained on the basis of this approach was in agreement with the real efficacy of the course therapy in 84% of all cases.
为了有助于对治疗效果进行个体预测，作者阐述了一种新方法，用于分析临床和药代动力学参数对精神药物试验剂量预处理给药的反应。上述方法用于氯氮平的多中心临床药代动力学研究，该研究涉及来自六个国家的十个研究中心，共有136名患者。根据临床和药代动力学参数，获得了一个累积指数，并确定了其预测潜力。基于这种方法获得的情感预后评估在84%的所有病例中与疗程治疗的实际疗效一致。
