Philipsen T, Nørgård M
Acta Obstet Gynecol Scand. 1984;63(1):51-5. doi: 10.3109/00016348409156273.
Survival after treatment of stage I endometrial adenocarcinoma was studied in a material of 111 patients, median follow-up period 6 years. Routine treatment was preoperative intrauterine and vaginal radium followed, in 6 weeks, by total hysterectomy and bilateral salpingo-oophorectomy. The 5-year corrected survival after treatment by operation and/or irradiation was 93%, after irradiation alone 87%. A significantly better survival was found in stage Ia (95%) than in stage Ib (83%) and also in patients with grade 1 tumors (97%) than in those with grade 3 tumors (71%). 21% of the patients had a residual endometrial tumor after preoperative radium, and among them survival was significantly lower than in patients without residual tumor. The recurrence rate was 11.7%. Vaginal metastases did not occur. Our routine treatment afford satisfactory results in stage I, grade 1 and 2. However, supplementary treatment must be recommended in the case of grade 3 tumors, of myometrial deep invasion, and of residual tumor following preoperative radium therapy.
对111例I期子宫内膜腺癌患者的治疗后生存情况进行了研究，中位随访期为6年。常规治疗为术前宫腔及阴道镭疗，6周后行全子宫切除术及双侧输卵管卵巢切除术。手术和/或放疗后的5年校正生存率为93%，单纯放疗为87%。Ia期（95%）的生存率显著高于Ib期（83%），1级肿瘤患者（97%）的生存率也高于3级肿瘤患者（71%）。21%的患者术前镭疗后有残留子宫内膜肿瘤，其中生存率显著低于无残留肿瘤的患者。复发率为11.7%。未发生阴道转移。我们的常规治疗在I期、1级和2级患者中取得了满意的结果。然而，对于3级肿瘤、子宫肌层深度浸润以及术前镭疗后有残留肿瘤的情况，必须推荐辅助治疗。
