Roitbak A I
Acta Neurobiol Exp (Wars). 1984;44(1):41-9.
Tetanic stimulation of the cortex elicits in some cortical neurons a hyperpolarizing change of the membrane potential and inhibition of impulse activity; after cessation of stimulation often an enhanced discharge occurs. Other neurons respond to stimulation with high-frequency discharges. At the site of stimulation [K+]o is increased more than by 2 mM. If tetanic stimulations are applied at less than 2 min intervals they result in an attenuated K+ release. During tetanic stimulation of the cortex a depolarizing shift of the glial cell membrane potential develops at all strata of the cortex. It is known that conditioned reflex may be elaborated when the electrical stimulation of the motor cortex is used as unconditioned stimulus if the intertrial intervals are not too short. It is hypothesized that the effectiveness of the stimulation of the cortex in eliciting the K+ release and in promoting a conditioned reflex acquisition are interrelated. According to this hypothesis an increase in [K+]o is a signal for myelin formation, and myelination of the naked axonic terminals which convey conditioned signal is the basis for the conversion of the potential connections into the actual ones.
对皮层进行强直刺激会在一些皮层神经元中引发膜电位的超极化变化以及冲动活动的抑制；刺激停止后，常常会出现放电增强的情况。其他神经元则以高频放电对刺激做出反应。在刺激部位，细胞外钾离子浓度升高超过2 mM。如果以小于2分钟的间隔施加强直刺激，它们会导致钾离子释放减弱。在对皮层进行强直刺激期间，皮层各层的神经胶质细胞膜电位都会出现去极化偏移。已知如果试验间隔时间不太短，当将运动皮层的电刺激用作非条件刺激时，可以建立条件反射。据推测，皮层刺激在引发钾离子释放以及促进条件反射形成方面的有效性是相互关联的。根据这一假设，细胞外钾离子浓度的升高是髓鞘形成的信号，而传递条件信号的裸露轴突终末的髓鞘化是潜在连接转化为实际连接的基础。
