Marr J J
Adv Exp Med Biol. 1984;165 Pt A:231-7. doi: 10.1007/978-1-4684-4553-4_45.
The demonstration of this unusual metabolic sequence in these organisms indicates that there are substantial differences between these protozoans and their mammalian hosts with respect to pyrazolopyrimidine metabolism. The intracellular forms of L. donovani, which are the pathogenic agents of the human disease, metabolize allopurinol identically. Trypanosoma cruzi, the causative agent of American trypanosomiasis, metabolizes allopurinol in the same manner as leishmania; in addition, the intracellular and bloodstream forms of this organism, the agents of the disease in man, carry out the same reaction sequence. The African trypanosomes, T. rhodesiense and T. brucei also convert allopurinol to the same metabolic products. These metabolic sequences appear to be common to most of the pathogenic hemoflagellate parasites that infect man and this opens a new avenue of research in purine metabolism.
在这些生物体中这种不寻常代谢序列的证明表明，就吡唑并嘧啶代谢而言，这些原生动物与其哺乳动物宿主之间存在显著差异。杜氏利什曼原虫的细胞内形式是人类疾病的病原体，其代谢别嘌呤醇的方式相同。克氏锥虫是美洲锥虫病的病原体，其代谢别嘌呤醇的方式与利什曼原虫相同；此外，该生物体的细胞内形式和血液形式是人类疾病的病原体，它们进行相同的反应序列。非洲锥虫，即罗德西亚锥虫和布氏锥虫，也将别嘌呤醇转化为相同的代谢产物。这些代谢序列似乎是大多数感染人类的致病性血鞭毛虫寄生虫所共有的，这为嘌呤代谢研究开辟了一条新途径。
