Martinez S, Looker D L, Berens R L, Marr J J
Department of Medicine, University of Cauca, Popoyan, Colombia.
Am J Trop Med Hyg. 1988 Sep;39(3):250-5. doi: 10.4269/ajtmh.1988.39.250.
Pyrazolopyrimidines, particularly allopurinol, allopurinol riboside, and other purine analogues, show promise as experimental therapeutic compounds for the treatment of leishmaniasis. The combination of these agents with pentostam may produce an improved therapeutic effect. We report here on strong synergistic activity between pyrazolopyrimidines and pentavalent antimonials in a human macrophage tissue culture system infected with Leishmania donovani and L. braziliensis.
吡唑并嘧啶类化合物，特别是别嘌呤醇、别嘌呤醇核糖苷及其他嘌呤类似物，作为治疗利什曼病的实验性治疗化合物显示出前景。这些药物与喷他脒联合使用可能会产生更好的治疗效果。我们在此报告在感染杜氏利什曼原虫和巴西利什曼原虫的人巨噬细胞组织培养系统中，吡唑并嘧啶类化合物与五价锑剂之间具有强大的协同活性。
