非洲锥虫中吡唑并嘧啶的代谢：与克氏锥虫和利什曼原虫属的代谢相似性
Pyrazolopyrimidine metabolism in African trypanosomes: metabolic similarities to Trypanosoma cruzi and Leishmania spp.
作者信息
Berens R L, Marr J J, Brun R
出版信息
Mol Biochem Parasitol. 1980 Apr;1(2):69-73. doi: 10.1016/0166-6851(80)90001-8.
Growth inhibition and radioisotope incorporation studies with allopurinol (4-hydroxypyrazolo(3,4-d)pyrimidine) have shown that the African trypanosomes are biologically and biochemically similar to Leishmania spp. and Trypanosoma cruzi with respect to their response to this compound. These organisms, as a group, share the unique ability to convert allopurinol sequentially to its ribonucleoside monophosphate and 4-aminopyrazolo(3,4-d)pyrimidine ribonucleoside mono-, di- and triphosphates.
用别嘌呤醇（4-羟基吡唑并[3,4-d]嘧啶）进行的生长抑制和放射性同位素掺入研究表明，非洲锥虫在对该化合物的反应方面，在生物学和生物化学上与利什曼原虫属和克氏锥虫相似。作为一个群体，这些生物体具有独特的能力，能够将别嘌呤醇依次转化为其核糖核苷单磷酸以及4-氨基吡唑并[3,4-d]嘧啶核糖核苷单磷酸、二磷酸和三磷酸。
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