Townsend R J, Benedetti T J, Erickson S H, Cengiz C, Gillespie W R, Gschwend J, Albert K S
Am J Obstet Gynecol. 1984 May 15;149(2):184-6. doi: 10.1016/0002-9378(84)90195-9.
Concentrations of ibuprofen in breast milk and serum were compared in 12 patients who had ingested one 400 mg tablet of ibuprofen every 6 hours over a 24-hour period for relief of post-cesarean section pain. Samples of breast milk and blood were obtained simultaneously over a 34-hour period beginning just prior to the first dose of ibuprofen. Gas-liquid chromatography assay methodology capable of detecting 1 microgram/ml was used to determine concentrations of ibuprofen in serum and breast milk. Ibuprofen was present in the serum with a half-life of approximately 1.5 hours. No measurable amounts of ibuprofen were found in the samples of breast milk. The conclusion drawn is that, in lactating women who take up to 400 mg of ibuprofen every 6 hours, less than 1 mg of ibuprofen per day is excreted in breast milk.
对12名因剖宫产后疼痛而每6小时服用一片400毫克布洛芬持续24小时的患者，比较了其母乳和血清中布洛芬的浓度。在第一剂布洛芬服用前开始的34小时内，同时采集母乳和血液样本。采用能够检测1微克/毫升的气液色谱分析方法来测定血清和母乳中布洛芬的浓度。血清中存在布洛芬，其半衰期约为1.5小时。在母乳样本中未发现可测量量的布洛芬。得出的结论是，在每6小时服用高达400毫克布洛芬的哺乳期妇女中，母乳中每天排出的布洛芬少于1毫克。
