肝病患者血清中N-乙酰-β-氨基葡萄糖苷酶同工酶P（作者译）

[Isoenzyme P of N-acetyl-beta-glucosaminidase in sera from patients with liver diseases (author's transl)].

作者信息

Pott G, Eberhardt G, Gerlach U

出版信息

Klin Wochenschr. 1978 Jul 1;56(13):681-2. doi: 10.1007/BF01477023.

DOI:10.1007/BF01477023

Abstract

The isoenzyme P of N-Acetyl-beta-Glucosaminidase (beta-NAG) is demonstrated in sera from healthy persons and patients with acute and chronic liver diseases by electrofocusing in polyacrylamide gel. Elevation of isoenzyme P is observed only together with elevation of Glutamate-Pyruvate-Transaminase (GPT) in patients with acute and chronic liver diseases of different etiology and activity. The correlation between isoenzyme P and GPT is significant. On the contrary whole beta-NAG is elevated due the activity of the mesenchymal reaction in the injured liver tissue, not related to enzymes of the cytosol like GPT.

摘要

通过在聚丙烯酰胺凝胶中进行电聚焦，在健康人以及急慢性肝病患者的血清中证实了N-乙酰-β-葡萄糖苷酶（β-NAG）的同工酶P。在不同病因和活动程度的急慢性肝病患者中，仅在谷氨酸丙酮酸转氨酶（GPT）升高的同时观察到同工酶P升高。同工酶P与GPT之间的相关性显著。相反，由于受损肝组织中间质反应的活性，整个β-NAG升高，这与像GPT这样的胞质溶胶酶无关。

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[Activity determination of lysosomal and cytoplasmic enzymes in the human serum in liver diseases].[肝脏疾病患者血清中溶酶体酶和细胞质酶的活性测定]

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Clin Chim Acta. 1973 Jul 27;46(4):455-64. doi: 10.1016/0009-8981(73)90259-3.

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