Jones D D, Williams G F, Prochazka B
Enzyme. 1975;20(3):129-37. doi: 10.1159/000458931.
The antisera to the A and B isoenzymes found in placenta and fetal liver were raised in rabbits. No antigenic difference was found between the fetal liver and adult tissue isoenzymes. Antisera to the placental isoenzymes did not react with the isoenzymes of adult tissues. The antibody raised against the placental B and fetal B liver isoenzyme decreased the N-acetyl-beta-glucosaminidase activity in maternal serum at 38 weeks gestation to the value found in normal human serum. Immunological evidence has been presented that the isoenzyme of N-acetyl-beta-glucosaminidase found only in pregnancy serum was of placental origin.
针对胎盘和胎儿肝脏中发现的A和B同工酶的抗血清是在兔子体内产生的。未发现胎儿肝脏同工酶与成人组织同工酶之间存在抗原差异。针对胎盘同工酶的抗血清不与成人组织的同工酶发生反应。针对胎盘B和胎儿B肝脏同工酶产生的抗体，使妊娠38周时母体血清中的N-乙酰-β-氨基葡萄糖苷酶活性降至正常人血清中的水平。已有免疫学证据表明，仅在妊娠血清中发现的N-乙酰-β-氨基葡萄糖苷酶同工酶来源于胎盘。
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