Flickinger E G, Pories W J, Meelheim H D, Sinar D R, Blose I L, Thomas F T
Ann Surg. 1984 May;199(5):555-62. doi: 10.1097/00000658-198405000-00010.
Two hundred and ten morbidly obese patients underwent a standardized gastric bypass procedure between February 1980 and November 1983. We conclude, based on 100% follow-up, that the operation is safe (operative mortality--1%, significant complications--10%) and effective (reoperation rate--4%). Only one patient failed to lose more than 25% of preoperative weight. The operation produced a mean weight loss in the group from 289 pounds (202-505) before surgery to 176 pounds (118-308) at 18 months after surgery. Stated as "per cent of ideal weight," patients lost from a preoperative mean of 214% (153-350) to 130% (88-189) at 18 months. Maximum weight loss was reached by 18 months after the procedure and was maintained during 36 months of observation in over 95% of patients. When patients were divided into four groups according to preoperative weight, weight loss occurred at a roughly similar rate, but heavier patients, although they lost more weight, plateaued at a higher weight than patients originally less obese. Striking and objective benefits were seen in patients with diabetes, hypertension, heart disease, and pulmonary insufficiency.
1980年2月至1983年11月期间，210例病态肥胖患者接受了标准化的胃旁路手术。基于100%的随访，我们得出结论：该手术是安全的（手术死亡率为1%，严重并发症发生率为10%）且有效（再次手术率为4%）。只有1例患者术后体重减轻未超过术前体重的25%。该组患者的平均体重从术前的289磅（202 - 505磅）降至术后18个月时的176磅（118 - 308磅）。以“理想体重百分比”表示，患者术前平均为214%（153 - 350），术后18个月降至130%（88 - 189）。术后18个月达到最大体重减轻，并且在超过95%的患者36个月的观察期内体重得以维持。根据术前体重将患者分为四组，体重减轻的速率大致相似，但体重较重的患者，尽管减重更多，但其体重稳定在比原本不太肥胖的患者更高的水平。糖尿病、高血压、心脏病和肺功能不全患者均出现了显著且客观的益处。
