Quine D B, Regan D, Beverley K I, Murray T J
Arch Neurol. 1984 May;41(5):506-8. doi: 10.1001/archneur.1984.04050170052016.
After exposure to a prolonged tone of changing intensity but constant frequency, controls, patients with peripheral hearing loss, and patients with multiple sclerosis (MS) demonstrated a reduced sensitivity to shifts in intensity; sensitivity to frequency shifts was unaffected. After exposure to a prolonged tone of changing frequency but constant intensity, control and patients with peripheral hearing loss demonstrated reduced sensitivity to shifts in frequency; sensitivity to intensity shifts was unaffected. Some patients with MS showed no loss of sensitivity to shifts in frequency. Our findings suggest that some patients with MS have abnormal mechanisms for processing changes of frequency. If such processing of frequency change is important for understanding speech, then this observation of a specific central hearing defect may help to explain poor speech discrimination in some patients with MS who have normal audiograms.
在暴露于强度变化但频率恒定的长时间纯音后，对照组、外周性听力损失患者和多发性硬化症（MS）患者对强度变化的敏感度降低；对频率变化的敏感度未受影响。在暴露于频率变化但强度恒定的长时间纯音后，对照组和外周性听力损失患者对频率变化的敏感度降低；对强度变化的敏感度未受影响。一些MS患者对频率变化的敏感度未丧失。我们的研究结果表明，一些MS患者在处理频率变化方面存在异常机制。如果这种频率变化处理对于理解言语很重要，那么这种特定的中枢性听力缺陷观察结果可能有助于解释一些听力图正常的MS患者言语辨别能力差的原因。
