Kish S J, Shannak K S, Rajput A H, Gilbert J J, Hornykiewicz O
Arch Neurol. 1984 Jun;41(6):612-4. doi: 10.1001/archneur.1984.04210080020007.
Norepinephrine was measured in postmortem cerebellar cortex of 22 non-neurological control subjects and nine patients with Parkinson's disease, using the high-performance liquid chromatography method with amperometric detection. In all control subjects, substantial amounts of norepinephrine was found in cerebellar cortex. There was a moderate negative correlation between age of control subjects and cerebellar norepinephrine concentration. In the patients with Parkinson's disease, the cerebellar cortical norepinephrine levels were significantly below normal. This is in accord with previously reported reduced norepinephrine levels in locus ceruleus and other regions of the parkinsonian brain. Although the main symptoms of Parkinson's disease are primarily caused by disturbed basal ganglia (dopamine) function, cerebellar dysfunction related to norepinephrine may contribute to some abnormalities of motor performance in this disorder.
采用高效液相色谱安培检测法，对22名非神经学对照受试者和9名帕金森病患者的死后小脑皮质中的去甲肾上腺素进行了测量。在所有对照受试者中，小脑皮质中发现了大量的去甲肾上腺素。对照受试者的年龄与小脑去甲肾上腺素浓度之间存在中度负相关。在帕金森病患者中，小脑皮质去甲肾上腺素水平显著低于正常水平。这与先前报道的帕金森病大脑蓝斑及其他区域去甲肾上腺素水平降低一致。尽管帕金森病的主要症状主要由基底神经节（多巴胺）功能紊乱引起，但与去甲肾上腺素相关的小脑功能障碍可能导致该疾病中一些运动表现异常。
