Toris C B, Pederson J E
Arch Ophthalmol. 1984 May;102(5):752-6. doi: 10.1001/archopht.1984.01040030600030.
Intravenous horseradish peroxidase (HRP) was administered to cynomolgus monkeys to study chorioretinal diffusion in eyes with retinal detachment. In control eyes, HRP was contained within the choriocapillaris and did not penetrate beyond Bruch's membrane. In addition, HRP was confined within blood vessels of the sensory retina. In detached eyes, HRP diffused out of the choriocapillaris and through the intercellular spaces of the retinal pigment epithelium (RPE), where it was blocked by zonulae occludentes. Occasionally HRP was found within pinocytotic vesicles of the RPE. It was also confined within retinal blood vessels by their endothelial cells. It is concluded that the blood-retinal barrier remains intact to HRP following long-term rhegmatogenous retinal detachment. However, a slight alteration exists at the choriocapillaris in detached eyes.
将静脉注射辣根过氧化物酶（HRP）用于食蟹猴，以研究视网膜脱离眼的脉络膜视网膜扩散情况。在对照眼中，HRP局限于脉络膜毛细血管内，未穿透布鲁赫膜。此外，HRP局限于感觉视网膜的血管内。在脱离的眼中，HRP从脉络膜毛细血管扩散出来，穿过视网膜色素上皮（RPE）的细胞间隙，在那里被紧密连接所阻挡。偶尔在RPE的吞饮小泡内发现HRP。它也被视网膜血管的内皮细胞限制在血管内。得出的结论是，长期孔源性视网膜脱离后，血视网膜屏障对HRP保持完整。然而，脱离眼的脉络膜毛细血管存在轻微改变。
