Macy J I, Minckler D S, Smith R E
Arch Ophthalmol. 1980 Dec;98(12):2217-9. doi: 10.1001/archopht.1980.01020041069015.
Rhesus monkey eyes were studied after the development of inflammatory serous retinal detachments following internal carotid artery injection of live, yeast-phase Histoplasma capsulatum organisms. Horseradish peroxidase (HRP) was used as a tracer to examine the inner and outer blood-retinal barriers. The HRP was present in a decreasing gradient from the choroid into the subretinal space and was not found to have leaked from retinal vessels. The source of subretinal fluid in this model of inflammatory serous retinal detachment was leakage from the choroid through a defective outer blood-retinal barrier, induced by disruption of the retinal pigment epithelium. This model has relevance to understanding the serous retinal detachments common to diseases affecting the choroid.
在向恒河猴颈内动脉注射活的酵母相荚膜组织胞浆菌后，出现了炎症性浆液性视网膜脱离，对其眼睛进行了研究。辣根过氧化物酶（HRP）被用作示踪剂，以检查内外血视网膜屏障。HRP从脉络膜到视网膜下间隙呈递减梯度存在，未发现其从视网膜血管渗漏。在这种炎症性浆液性视网膜脱离模型中，视网膜下液的来源是脉络膜通过视网膜色素上皮破坏所诱导的有缺陷的外血视网膜屏障渗漏。该模型对于理解影响脉络膜的疾病中常见的浆液性视网膜脱离具有重要意义。
