来自对放疗有已知反应患者的早期传代鳞状细胞癌系的细胞X射线修复参数。
Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
作者信息
Weichselbaum R, Dahlberg W, Little J B, Ervin T J, Miller D, Hellman S, Rheinwald J G
出版信息
Br J Cancer. 1984 May;49(5):595-601. doi: 10.1038/bjc.1984.94.
Abstract
We have investigated X-ray survival parameters and repair of potentially lethal damage ( PLDR ) in ten early passage squamous cell carcinoma cell lines derived from patients who were biopsied before initiation of radiotherapy or after radiation therapy failure. Radiosensitivity (D0) ranged from 1.07 to 1.93 (Gy), extrapolation numbers (-n) from 1.17 to 2.14 and PLD recovery at 24 h from 1.4 to 20.3. Despite significant differences in these parameters amongst the cell lines, a firm correlation between radiocurability and any individual radiobiological parameter could not be established. Our data suggest that the mechanisms associated with radioresistance are complex and that any single radiobiological parameter may not predict clinical success or failure.
摘要
我们研究了来自放疗开始前活检或放疗失败后活检患者的10个早期传代鳞状细胞癌细胞系的X射线存活参数和潜在致死性损伤（PLDR）的修复情况。放射敏感性（D0）范围为1.07至1.93（Gy），外推数（-n）为1.17至2.14，24小时时PLD恢复率为1.4至20.3。尽管这些参数在细胞系之间存在显著差异，但无法确定放射可治愈性与任何单个放射生物学参数之间的牢固相关性。我们的数据表明，与放射抗性相关的机制很复杂，任何单个放射生物学参数可能都无法预测临床的成功或失败。
相似文献
1
Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.来自对放疗有已知反应患者的早期传代鳞状细胞癌系的细胞X射线修复参数。
Br J Cancer. 1984 May;49(5):595-601. doi: 10.1038/bjc.1984.94.
2
Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2684-8. doi: 10.1073/pnas.83.8.2684.
3
Radiobiological characterization of head and neck and sarcoma cells derived from patients prior to radiotherapy.放疗前源自患者的头颈部及肉瘤细胞的放射生物学特征
Int J Radiat Oncol Biol Phys. 1990 Aug;19(2):313-9. doi: 10.1016/0360-3016(90)90539-v.
4
Comparison of cellular radiosensitivity between different localizations of head and neck squamous-cell carcinoma.头颈部鳞状细胞癌不同部位之间细胞放射敏感性的比较。
J Cancer Res Clin Oncol. 1995;121(8):452-6. doi: 10.1007/BF01218360.
5
The maximum recovery potential of human tumor cells may predict clinical outcome in radiotherapy.人类肿瘤细胞的最大恢复潜能可能预测放射治疗的临床结果。
Int J Radiat Oncol Biol Phys. 1987 May;13(5):709-13. doi: 10.1016/0360-3016(87)90289-6.
6
Radioresistant tumor cell lines derived from head and neck radiation failures.源自头颈部放疗失败患者的耐辐射肿瘤细胞系。
Head Neck. 1989 Jul-Aug;11(4):343-8. doi: 10.1002/hed.2880110410.
7
The inherent cellular radiosensitivity of epithelial ovarian carcinoma.上皮性卵巢癌固有的细胞放射敏感性。
Gynecol Oncol. 1989 Dec;35(3):282-5. doi: 10.1016/0090-8258(89)90063-2.
8
Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy.放射抗拒性肿瘤细胞存在于放疗后复发的头颈癌中。
Int J Radiat Oncol Biol Phys. 1988 Sep;15(3):575-9. doi: 10.1016/0360-3016(88)90297-0.
9
Radiation survival of two human cervical carcinoma cell lines after multifraction irradiation.两种人宫颈癌细胞系在多次分割照射后的辐射存活情况。
Int J Radiat Oncol Biol Phys. 1996 Jul 15;35(5):941-50. doi: 10.1016/0360-3016(96)00144-7.
10
Radiosensitivity of human head and neck squamous cell carcinomas in primary culture and its potential as a predictive assay of tumor radiocurability.原代培养的人头颈部鳞状细胞癌的放射敏感性及其作为肿瘤放射可治愈性预测检测方法的潜力。
Int J Radiat Biol. 1989 Nov;56(5):751-60. doi: 10.1080/09553008914552001.
引用本文的文献
1
Diffuse reflectance spectroscopy for optical characterizations of orthotopic head and neck cancer models .用于原位头颈癌模型光学表征的漫反射光谱法
Biomed Opt Express. 2024 Jun 10;15(7):4176-4189. doi: 10.1364/BOE.528608. eCollection 2024 Jul 1.
2
Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells.乙醇在永生化喉细胞中诱导复制叉停滞和膜应激。
iScience. 2023 Nov 23;26(12):108564. doi: 10.1016/j.isci.2023.108564. eCollection 2023 Dec 15.
3
A Novel Peptide for Simultaneously Enhanced Treatment of Head and Neck Cancer and Mitigation of Oral Mucositis.一种用于同时增强头颈癌治疗效果并减轻口腔黏膜炎的新型肽。
PLoS One. 2016 Apr 6;11(4):e0152995. doi: 10.1371/journal.pone.0152995. eCollection 2016.
4
Optical metabolic imaging of treatment response in human head and neck squamous cell carcinoma.人头颈部鳞状细胞癌治疗反应的光学代谢成像
PLoS One. 2014 Mar 4;9(3):e90746. doi: 10.1371/journal.pone.0090746. eCollection 2014.
5
A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence.一种涉及层粘连蛋白5和p16INK4A的角质形成细胞过度运动/生长停滞反应，在伤口愈合和衰老过程中被激活。
Am J Pathol. 2006 Jun;168(6):1821-37. doi: 10.2353/ajpath.2006.051027.
6
Effect of photodynamic therapy in combination with ionizing radiation on human squamous cell carcinoma cell lines of the head and neck.光动力疗法联合电离辐射对头颈部人鳞状细胞癌细胞系的影响。
Br J Cancer. 2000 Sep;83(5):655-61. doi: 10.1054/bjoc.2000.1328.
7
Inherently radioresistant cells exist in some human tumors.一些人类肿瘤中存在内在抗辐射细胞。
Proc Natl Acad Sci U S A. 1985 Jul;82(14):4732-5. doi: 10.1073/pnas.82.14.4732.
8
Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2684-8. doi: 10.1073/pnas.83.8.2684.
9
Differential response of human and rodent cell lines to chemical inhibition of the repair of potentially lethal damage.人类和啮齿动物细胞系对化学抑制潜在致死性损伤修复的差异反应。
Radiat Environ Biophys. 1989;28(3):193-202. doi: 10.1007/BF01211256.
10
Platinum-dye complexes inhibit repair of potentially lethal damage following bleomycin treatment.铂染料复合物可抑制博来霉素治疗后潜在致死性损伤的修复。
Br J Cancer. 1989 May;59(5):722-6. doi: 10.1038/bjc.1989.152.
本文引用的文献
1
X-ray damage and recovery in mammalian cells in culture.培养的哺乳动物细胞中的X射线损伤与恢复
Nature. 1959 Oct 24;184:1293-5. doi: 10.1038/1841293a0.
2
3
4
In vitro cellular radiosensitivity of human malignant melanoma.人恶性黑色素瘤的体外细胞放射敏感性
Int J Radiat Oncol Biol Phys. 1982 Jul;8(7):1235-7. doi: 10.1016/0360-3016(82)90074-8.
5
Cellular repair factors influencing radiocurability of human malignant tumours.影响人类恶性肿瘤放射可治愈性的细胞修复因子
Br J Cancer. 1982 Jan;45(1):10-6. doi: 10.1038/bjc.1982.2.
6
The effects of lexA101, recB21, recF143 and uvrD3 mutations on liquid-holding recovery in ultraviolet-irradiated Escherichia coli K12 recA56.lexA101、recB21、recF143和uvrD3突变对紫外线照射的大肠杆菌K12 recA56液体保存复苏的影响。
Mutat Res. 1981 Jan;80(1):15-25. doi: 10.1016/0027-5107(81)90174-3.
7
Purine nucleoside analogues inhibit the repair of radiation-induced potentially lethal damage in mammalian cells in culture.嘌呤核苷类似物可抑制培养的哺乳动物细胞中辐射诱导的潜在致死性损伤的修复。
Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Mar;41(3):343-6. doi: 10.1080/09553008214551801.
8
Inhibition of X-ray-induced potentially lethal damage (PLD) repair by cordycepin (3'-deoxyadenosine) and enhancement of its action by 2'-deoxycoformycin in Chinese hamster hai cells in the stationary phase in vitro.虫草素（3'-脱氧腺苷）对体外静止期中国仓鼠细胞中X射线诱导的潜在致死性损伤（PLD）修复的抑制作用以及2'-脱氧助间型霉素对其作用的增强作用
Radiat Res. 1980 Nov;84(2):265-75.
9
X-ray sensitivity of human tumor cells in vitro.人肿瘤细胞在体外的X射线敏感性
Int J Radiat Oncol Biol Phys. 1980 Apr;6(4):437-40. doi: 10.1016/0360-3016(80)90057-7.
Zotero 插件