一些人类肿瘤中存在内在抗辐射细胞。
Inherently radioresistant cells exist in some human tumors.
作者信息
Weichselbaum R R, Dahlberg W, Little J B
出版信息
Proc Natl Acad Sci U S A. 1985 Jul;82(14):4732-5. doi: 10.1073/pnas.82.14.4732.
Abstract
We investigated the survival of 29 human tumor cell lines after treatment with ionizing radiation during exponential growth. The radiosensitivity of 20 tumor cell lines was within the range of normal fibroblasts. However, 9 cell lines derived from radio-incurable tumors appeared inherently radioresistant. When the ability to repair potentially lethal x-ray damage was studied in plateau phase cultures, some tumor cell lines derived from radio-incurable tumors were more efficient in this process. These results indicate that the presence of radioresistant and/or repair-proficient cells, which exist in some human tumors, may be responsible for failure to obtain local control following therapeutic x-ray treatment.
摘要
我们研究了29种人类肿瘤细胞系在指数生长期接受电离辐射后的存活情况。20种肿瘤细胞系的放射敏感性在正常成纤维细胞的范围内。然而，9种源自放射治疗无法治愈的肿瘤的细胞系表现出固有的放射抗性。当在平台期培养物中研究修复潜在致死性X射线损伤的能力时，一些源自放射治疗无法治愈的肿瘤的肿瘤细胞系在这个过程中效率更高。这些结果表明，某些人类肿瘤中存在的放射抗性和/或修复能力强的细胞可能是导致治疗性X射线治疗后未能实现局部控制的原因。
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