影响人类恶性肿瘤放射可治愈性的细胞修复因子
Cellular repair factors influencing radiocurability of human malignant tumours.
作者信息
Weichselbaum R R, Schmit A, Little J B
出版信息
Br J Cancer. 1982 Jan;45(1):10-6. doi: 10.1038/bjc.1982.2.
Abstract
We have studied the repair of X-ray-induced, potentially lethal damage (PLD) in 9 human tumour lines derived from tumours of varying radiocurability. Cells derived from 3 tumours considered non-radiocurable (1 osteosarcoma, 2 melanoma) repaired significantly more X-ray PLD than cells from 3 tumours considered radiocurable (2 breast, 1 neuroblastoma). The remaining tumour lines were intermediate in their ability for repair, and included cells from another osteosarcoma, a hypernephroma and a glioblastoma. We conclude that the repair of X-ray PLD may be an important cellular determinant of clinical radiocurability.
摘要
我们研究了来自不同放射可治愈性肿瘤的9种人类肿瘤细胞系中X射线诱导的潜在致死性损伤（PLD）的修复情况。来自3种被认为不可放射治愈的肿瘤（1例骨肉瘤、2例黑色素瘤）的细胞比来自3种被认为可放射治愈的肿瘤（2例乳腺癌、1例神经母细胞瘤）的细胞修复X射线PLD的能力明显更强。其余肿瘤细胞系的修复能力处于中等水平，包括来自另1例骨肉瘤、1例肾细胞癌和1例胶质母细胞瘤的细胞。我们得出结论，X射线PLD的修复可能是临床放射可治愈性的一个重要细胞决定因素。
相似文献
1
Cellular repair factors influencing radiocurability of human malignant tumours.影响人类恶性肿瘤放射可治愈性的细胞修复因子
Br J Cancer. 1982 Jan;45(1):10-6. doi: 10.1038/bjc.1982.2.
2
Potentially lethal damage repair as a possible determinant of human tumour radiosensitivity.
Radiother Oncol. 1984 Jan;1(3):263-9. doi: 10.1016/s0167-8140(84)80009-2.
3
The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process.人类肿瘤对分次放疗的不同反应可能归因于照射后的修复过程。
Br J Cancer. 1982 Oct;46(4):532-7. doi: 10.1038/bjc.1982.237.
4
Differential radiosensitization of human tumour cells by 3-aminobenzamide and benzamide: inhibitors of poly(ADP-ribosylation).
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Dec;50(6):961-72. doi: 10.1080/09553008614551381.
5
Potentially lethal damage repair in cell lines of radioresistant human tumours and normal skin fibroblasts.
Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Sep;48(3):431-9. doi: 10.1080/09553008514551431.
6
Radioresistant and repair proficient cells may determine radiocurability in human tumors.
Int J Radiat Oncol Biol Phys. 1986 Apr;12(4):637-9. doi: 10.1016/0360-3016(86)90073-8.
7
Inhibition of potentially lethal radiation damage repair in normal and neoplastic human cells by 3-aminobenzamide: an inhibitor of poly(ADP-ribosylation).
Int J Radiat Oncol Biol Phys. 1986 Aug;12(8):1541-5. doi: 10.1016/0360-3016(86)90212-9.
8
Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.来自对放疗有已知反应患者的早期传代鳞状细胞癌系的细胞X射线修复参数。
Br J Cancer. 1984 May;49(5):595-601. doi: 10.1038/bjc.1984.94.
9
The maximum recovery potential of human tumor cells may predict clinical outcome in radiotherapy.人类肿瘤细胞的最大恢复潜能可能预测放射治疗的临床结果。
Int J Radiat Oncol Biol Phys. 1987 May;13(5):709-13. doi: 10.1016/0360-3016(87)90289-6.
10
Repair of fractionated radiation in plateau phase cultures of human tumor cells and human multicellular tumor spheroids.
Radiother Oncol. 1984 Jun;2(1):41-7. doi: 10.1016/s0167-8140(84)80037-7.
引用本文的文献
1
Elevated HDAC activity and altered histone phospho-acetylation confer acquired radio-resistant phenotype to breast cancer cells.组蛋白去乙酰化酶活性升高和组蛋白磷酸化乙酰化改变赋予乳腺癌细胞获得性放射抵抗表型。
Clin Epigenetics. 2020 Jan 3;12(1):4. doi: 10.1186/s13148-019-0800-4.
2
Potential lethal damage repair in glioblastoma cells irradiated with ion beams of various types and levels of linear energy transfer.不同类型和线性能量传递水平的离子束辐照胶质母细胞瘤细胞后的潜在致死性损伤修复
J Radiat Res. 2019 Jan 1;60(1):59-68. doi: 10.1093/jrr/rry081.
3
The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process.人类肿瘤对分次放疗的不同反应可能归因于照射后的修复过程。
Br J Cancer. 1982 Oct;46(4):532-7. doi: 10.1038/bjc.1982.237.
4
Establishment, characterization, and response to cytotoxic and radiation treatment of three human melanoma cell lines.三种人黑色素瘤细胞系的建立、特性鉴定及其对细胞毒性和放射治疗的反应
In Vitro. 1983 Jun;19(6):453-61. doi: 10.1007/BF02619592.
5
Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.来自对放疗有已知反应患者的早期传代鳞状细胞癌系的细胞X射线修复参数。
Br J Cancer. 1984 May;49(5):595-601. doi: 10.1038/bjc.1984.94.
6
The radiation response of V79 and human tumour multicellular spheroids--cell survival and growth delay studies.V79细胞和人肿瘤多细胞球体的辐射反应——细胞存活及生长延迟研究
Br J Cancer. 1984 Aug;50(2):143-51. doi: 10.1038/bjc.1984.156.
7
Radiation, heat and anti-melanin drug response of a transformed mouse embryo cell line with varying melanin content.具有不同黑色素含量的转化小鼠胚胎细胞系的辐射、热及抗黑色素药物反应
Br J Cancer. 1987 Nov;56(5):622-4. doi: 10.1038/bjc.1987.254.
8
High intrinsic radiosensitivity of a newly established and characterised human embryonal rhabdomyosarcoma cell line.一种新建立并鉴定的人胚胎横纹肌肉瘤细胞系具有高内在放射敏感性。
Br J Cancer. 1989 Feb;59(2):160-4. doi: 10.1038/bjc.1989.34.
9
Platinum-dye complexes inhibit repair of potentially lethal damage following bleomycin treatment.铂染料复合物可抑制博来霉素治疗后潜在致死性损伤的修复。
Br J Cancer. 1989 May;59(5):722-6. doi: 10.1038/bjc.1989.152.
10
Platinum complexes inhibit repair of potentially lethal damage following bleomycin treatment.铂配合物可抑制博来霉素治疗后潜在致死性损伤的修复。
Br J Cancer. 1987 Mar;55(3):245-8. doi: 10.1038/bjc.1987.47.
本文引用的文献
1
X-ray damage and recovery in mammalian cells in culture.培养的哺乳动物细胞中的X射线损伤与恢复
Nature. 1959 Oct 24;184:1293-5. doi: 10.1038/1841293a0.
2
3
Survival of irradiated glia and glioma cells studied with a new cloning technique.
Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Mar;37(3):267-79. doi: 10.1080/09553008014550321.
4
X-ray sensitivity of human tumor cells in vitro.人肿瘤细胞在体外的X射线敏感性
Int J Radiat Oncol Biol Phys. 1980 Apr;6(4):437-40. doi: 10.1016/0360-3016(80)90057-7.
5
Repair of sub-lethal and potentially lethal radiation damage in plateau phase cultures of human cells.人细胞平台期培养物中亚致死性和潜在致死性辐射损伤的修复
Nature. 1969 Nov 22;224(5221):804-6. doi: 10.1038/224804a0.
6
Stable chromosome changes in human malignant melanoma.
Cancer Res. 1973 Sep;33(9):2042-7.
7
Repair of potentially lethal radiation damage in vitro and in vivo.体内外潜在致死性辐射损伤的修复
Radiology. 1973 Mar;106(3):689-94. doi: 10.1148/106.3.689.
8
Plateau-phase cultures of mammalian cells: an in vitro model for human cancer.哺乳动物细胞的平台期培养：一种人类癌症的体外模型。
Curr Top Radiat Res Q. 1972 Jul;8(1):39-43.
9
Life-cycle dependence of repair of potentially-lethal radiation damage.
Int J Radiat Biol Relat Stud Phys Chem Med. 1973 Apr;23(4):401-7. doi: 10.1080/09553007314550451.
10
A human cell line from a pleural effusion derived from a breast carcinoma.一株源自乳腺癌胸腔积液的人细胞系。
J Natl Cancer Inst. 1973 Nov;51(5):1409-16. doi: 10.1093/jnci/51.5.1409.
Zotero 插件