Cappellini M D, Potter C G, Wood W G
Br J Haematol. 1984 May;57(1):61-70. doi: 10.1111/j.1365-2141.1984.tb02865.x.
Haemopoiesis in human fetal liver is almost entirely restricted to the erythroid series but when fetal liver cells were cultured under conditions established for the long-term maintenance of adult marrow haemopoiesis, a rapid switch to granulopoiesis was observed. Erythroid progenitor cells (BFU-E) rapidly disappeared, even though no humoral or cellular inhibitors of erythropoiesis could be detected, while myeloid progenitors (CFU-GM) increased in number. When the fetal liver cells were seeded onto stromal layers derived from adult marrow, in which endogenous haemopoiesis had ceased, granulopoiesis was established and maintained for more than a year, considerably longer than has previously been achieved with human haemopoietic cells.
人类胎儿肝脏中的造血几乎完全局限于红系，但当胎儿肝细胞在为长期维持成人骨髓造血而建立的条件下培养时，观察到迅速转向粒系造血。红系祖细胞（BFU-E）迅速消失，尽管未检测到任何红细胞生成的体液或细胞抑制剂，而髓系祖细胞（CFU-GM）数量增加。当将胎儿肝细胞接种到源自成人骨髓的基质层上时，其中内源性造血已经停止，粒系造血得以建立并维持了一年多，比以前用人造血细胞所达到的时间长得多。
