Handlos V
Biomaterials. 1984 Mar;5(2):81-5. doi: 10.1016/0142-9612(84)90005-x.
The design of a sterilizer for sterilization of heat sensitive items using gaseous formaldehyde and steam is described. The sterilizer is able to create a constant formaldehyde-steam concentration over a period of at least one hour. It is further able to operate at formaldehyde concentrations close to saturation with only small residues on sterilized plastic materials. The autoclave is used for measurement of formaldehyde solubility in polyolefines and poly(vinyl chloride) being approx. 15 and 250 ppm, respectively, at 70 degrees C and 30 mg HCHO I-1. The diffusion coefficient of formaldehyde in poly(vinyl chloride) is measured and is in the same order of magnitude as for ethylene oxide in poly(methyl methacrylate) i.e. 10(-10) cm2 s-1. Measurements of airborne formaldehyde in front of different sterilizers show that it is possible to design facilities meeting occupational exposure limits.
本文描述了一种使用气态甲醛和蒸汽对热敏物品进行灭菌的灭菌器的设计。该灭菌器能够在至少一小时的时间内保持恒定的甲醛 - 蒸汽浓度。它还能够在接近饱和的甲醛浓度下运行，且在灭菌后的塑料材料上仅残留少量物质。该高压灭菌器用于测量甲醛在聚烯烃和聚氯乙烯中的溶解度，在70摄氏度和30毫克甲醛/升的条件下，其溶解度分别约为15 ppm和250 ppm。测量了甲醛在聚氯乙烯中的扩散系数，其数量级与环氧乙烷在聚甲基丙烯酸甲酯中的扩散系数相同，即10^(-10) 平方厘米/秒。对不同灭菌器前空气中甲醛的测量表明，设计符合职业接触限值的设施是可能的。
