Vazina I R, Pylaeva S I, Vasil'chuk O A
Biull Eksp Biol Med. 1984 May;97(5):542-4.
Bacteriological assay, cytochemical studies of succinate and malate dehydrogenases, acid phosphatase, glycogen and lipids, as well as electron microscopy were used in experiments on 75 rabbits to examine over time phagocytosis of alveolar macrophages and some mechanisms of its disturbance after burn trauma. It was established that the phagocytic function of alveolar macrophages gets disturbed shortly after trauma, remaining depressed up to the time of convalescence. It was demonstrated that the mechanism by which phagocytic function gets disturbed differs with time following trauma. Primary depression of phagocytosis occurs immediately after burn. At the height of burn disease the cells develop an energy deficient state, whereas the time of convalescence is marked by the emergence of poorly differentiated forms of macrophages having the reduced phagocyte capacity.
在75只兔子身上进行的实验中，采用了细菌学检测、琥珀酸脱氢酶和苹果酸脱氢酶的细胞化学研究、酸性磷酸酶、糖原和脂质的研究以及电子显微镜检查，以长期观察肺泡巨噬细胞的吞噬作用及其在烧伤创伤后受到干扰的一些机制。结果表明，肺泡巨噬细胞的吞噬功能在创伤后不久就受到干扰，直到恢复期仍处于抑制状态。结果表明，吞噬功能受到干扰的机制随创伤后的时间而不同。吞噬作用的原发性抑制在烧伤后立即发生。在烧伤疾病的高峰期，细胞会出现能量缺乏状态，而在恢复期，则以出现吞噬能力降低的低分化巨噬细胞形式为特征。
