Harmon J W, Skornik W A, McDonald J, Dressler D P
Am J Surg. 1976 Apr;131(4):447-51. doi: 10.1016/0002-9610(76)90155-0.
The alveolar macrophage was studied in parabiotic rats using an inbred strain. Parabiotic pairs were sutured together at five weeks of age. Rats were subjected to a full thickness cutaneous burn of 20 per cent of the body surface area at seven weeks of age, and alveolar macrophages were washed from the lungs at six days post burn. The number of alveolar macrophages, their per cent of activation, and their ability to phagocytize and kill P aeruginosa in vitro were significantly increased at six days post burn in the burned controls and in both the burned and unburned members of the parabiotic pairs. No change in the alveolar macrophages was found in either unburned parabiotic pairs or in those which were sham-burned. These results indicate that a humoral or cellular agent produced either within the cutaneous burn wound or elsewhere as a response to the injury, traverses the parabiotic cross circulation to stimulate the alveolar macrophages.
使用近交系对联体大鼠的肺泡巨噬细胞进行了研究。联体对在5周龄时缝合在一起。大鼠在7周龄时遭受20%体表面积的全层皮肤烧伤，并在烧伤后6天从肺中冲洗出肺泡巨噬细胞。在烧伤对照组以及联体对中烧伤和未烧伤的成员中，烧伤后6天肺泡巨噬细胞的数量、其活化百分比以及它们在体外吞噬和杀死铜绿假单胞菌的能力均显著增加。在未烧伤的联体对或假烧伤的联体对中，肺泡巨噬细胞均未发现变化。这些结果表明，在皮肤烧伤伤口内或作为对损伤的反应在其他部位产生的体液或细胞因子，通过联体交叉循环刺激肺泡巨噬细胞。
