Marczynski T J, Burns L L, Livezey G T, Vimal R L, Chen E
Brain Res. 1984 Apr 23;298(1):75-90. doi: 10.1016/0006-8993(84)91148-x.
In behaving cats trained to press a bar for small aliquots of milk reward, single neuronal firing patterns were monitored from the nucleus reticularis (NR) thalami during bar bressing (BP), subsequent quiet wakefulness with EEG spindles (S- QW ), grooming behavior (GR) and slow-wave sleep (SWS). The temporal patterns in the neuronal spike trains were analyzed using a non-parametric method based on relative relations between sequential spike intervals. The deviations of pattern occurrences from the random model were quantified. During BP, specific patterns occurred much more often while others occurred much less often than predicted by the random model. Patterns that were dominant during BP, were selectively suppressed or virtually eliminated during S- QW , GR and SWS, despite the increased firing rate; and, vice versa, patterns that were suppressed below chance level during BP, became dominant during S- QW , GR and SWS. The magnitudes of these inversions of the statistical distribution of patterns were not random but graded and positively correlated, thus indicating that they were homeostatically controlled. Since the inversions were already evident shortly after the satiated ceased bar pressing, they may be related to the 'need' for sleep. On the basis of the known mechanisms of pattern generation and changes in receptors for putative transmitters, it was postulated that the inversions of pattern distribution are related to the recuperative function of SWS, i.e. resensitization of receptors that had been desensitized during the animal's stereotypic BP performance. The NR and other neuronal ensembles seem to constitute an oscillatory system with two modes of reciprocal connectivities : one is supporting wakefulness and emission of specific firing patterns, and the other is incompatible with wakefulness and instead is associated with inversion of statistical distribution of firing patterns and recuperative function of SWS.
在经过训练会按压杠杆以获取少量牛奶奖励的行为猫中，在杠杆按压（BP）、随后伴有脑电图纺锤波的安静觉醒（S-QW）、梳理行为（GR）和慢波睡眠（SWS）期间，监测丘脑网状核（NR）的单个神经元放电模式。使用基于连续尖峰间隔之间相对关系的非参数方法分析神经元尖峰序列中的时间模式。对模式出现与随机模型的偏差进行量化。在BP期间，特定模式出现的频率比随机模型预测的要高得多，而其他模式出现的频率则低得多。尽管放电率增加，但在BP期间占主导地位的模式在S-QW、GR和SWS期间被选择性抑制或几乎消除；反之，在BP期间被抑制到低于偶然水平的模式在S-QW、GR和SWS期间变得占主导地位。这些模式统计分布反转的幅度不是随机的，而是分级的且呈正相关，因此表明它们是通过稳态控制的。由于在饱腹的猫停止杠杆按压后不久反转就已经很明显，所以它们可能与睡眠“需求”有关。基于已知的模式生成机制和假定递质受体的变化，推测模式分布的反转与SWS的恢复功能有关，即在动物刻板的BP表现期间脱敏的受体的再敏化。NR和其他神经元集合似乎构成了一个具有两种相互连接模式的振荡系统：一种支持觉醒和特定放电模式的发射，另一种与觉醒不兼容，而是与放电模式的统计分布反转和SWS的恢复功能相关。
