Eriksson O, Hagmar B, Ryd W
Cancer. 1984 Jul 1;54(1):73-8. doi: 10.1002/1097-0142(19840701)54:1<73::aid-cncr2820540116>3.0.co;2-2.
Using five syngeneic tumor-host systems in mice, we studied the influence of fine-needle aspiration biopsy, incisional biopsy, and excisional biopsy on tumor death rates. Guided by results from pilot studies a very strict test protocol was developed which made possible a comparison between the tumor systems in spite of their differences in tumor growth rates and dissemination patterns. The compiled results from the experiments did not reveal any differences in tumor death rates, neither between the test groups and their controls, nor between the three biopsy methods: fine-needle aspiration biopsy, incisional biopsy, and excisional biopsy. Additional experiments confirmed, however, earlier observations that tumor cell seeding and tumor outgrowth by way of the aspiration needle track may occur under extreme test conditions.
我们使用五种小鼠同基因肿瘤宿主系统，研究了细针穿刺活检、切开活检和切除活检对肿瘤死亡率的影响。根据前期研究结果的指导，制定了一个非常严格的测试方案，尽管这些肿瘤系统在肿瘤生长速度和扩散模式上存在差异，但该方案仍使得对它们进行比较成为可能。实验汇总结果显示，无论是在测试组与其对照组之间，还是在细针穿刺活检、切开活检和切除活检这三种活检方法之间，肿瘤死亡率均未显示出任何差异。然而，额外的实验证实了早期的观察结果，即在极端测试条件下，可能会发生肿瘤细胞沿穿刺针道播种和肿瘤生长的情况。
