Kitahori Y, Hiasa Y, Konishi N, Enoki N, Shimoyama T, Miyashiro A
Carcinogenesis. 1984 May;5(5):657-60. doi: 10.1093/carcin/5.5.657.
The effect of 0.15% propylthiouracil (PTU) on thyroid tumorigenesis was studied in male Wistar rats given a single i.p. injection of 280 mg of N-bis(-2-hydroxypropyl)nitrosamine (DHPN) per 100 g body weight. The mean weights of the thyroid of rats treated with DHPN followed by PTU and with PTU alone were significantly higher than those of rats treated with DHPN only and control rats. The incidences of follicular adenoma at the end of week 20 of the experiment were 100% (21/21) in rats treated with DHPN followed by PTU, and 19% (4/21) in rats given DHPN alone. Papillary adenoma was observed in one rat treated with DHPN followed by PTU. The incidence of follicular carcinomas with invasive growth into the capsule, adipose tissues or blood vessels was 52% (11/21) in rats given DHPN and then PTU. No papillary carcinomas or solid tumors were found in any rats. Rats given PTU alone and untreated rats had no thyroid tumors. The serum concentration of T4 in rats treated with PTU alone was significantly lower than that in the control group. The serum concentration of T4 in rats treated with DHPN followed by PTU was slightly, but not significantly, lower than that in control rats. The serum concentrations of T3 in rats treated with DHPN followed by PTU, DHPN alone and PTU alone were also slightly, but not significantly, lower than that in controls.
在雄性Wistar大鼠中研究了0.15%丙硫氧嘧啶（PTU）对甲状腺肿瘤发生的影响，这些大鼠每100克体重经腹腔注射一次280毫克N-双（-2-羟丙基）亚硝胺（DHPN）。先给予DHPN再给予PTU的大鼠以及仅给予PTU的大鼠的甲状腺平均重量显著高于仅给予DHPN的大鼠和对照大鼠。实验第20周结束时，先给予DHPN再给予PTU的大鼠中滤泡性腺瘤的发生率为100%（21/21），仅给予DHPN的大鼠中为19%（4/21）。在一只先给予DHPN再给予PTU的大鼠中观察到乳头状腺瘤。在给予DHPN然后PTU的大鼠中，具有向包膜、脂肪组织或血管浸润性生长的滤泡癌发生率为52%（11/21）。在任何大鼠中均未发现乳头状癌或实体瘤。仅给予PTU的大鼠和未处理的大鼠没有甲状腺肿瘤。仅给予PTU的大鼠的血清T4浓度显著低于对照组。先给予DHPN再给予PTU的大鼠的血清T4浓度略低于对照大鼠，但差异不显著。先给予DHPN再给予PTU、仅给予DHPN和仅给予PTU的大鼠的血清T3浓度也略低于对照组，但差异不显著。
