原发性高血压达尔模型中的心肌胆碱能受体位点及酶活性

Myocardial cholinergic receptor sites and enzyme activity in the Dahl model of essential hypertension.

作者信息

McCaughran J A, Edwards E, Friedman R, Schechter N

出版信息

Clin Exp Hypertens A. 1984;6(4):811-26. doi: 10.3109/10641968409044040.

DOI:10.3109/10641968409044040

Abstract

The density of muscarinic receptor sites, choline acetyltransferase (ChAT), and acetylcholinesterase (AChE) activity in the myocardium of the Dahl salt-sensitive (DS) and salt-resistant (DR) rat was investigated. Both normotensive and hypertensive (as a result of 8.0% NaCl added to the diet) DS rats displayed a lower concentration of muscarinic receptors and less ChAT and AChE activity in myocardial tissue than normotensive DR rats. Lower receptor site density and enzyme activity in the myocardial of the DS line may reflect decreased vagal tone. If true, this may produce dificits in the ability to appropriately adjust heart rate (HR) in response to elevations in blood pressure (BP). Therefore, the present results may be viewed as exacerbational factors in the pathogenesis of hypertension in the DS line.

摘要

研究了 Dahl 盐敏感（DS）大鼠和盐抵抗（DR）大鼠心肌中毒蕈碱受体位点的密度、胆碱乙酰转移酶（ChAT）和乙酰胆碱酯酶（AChE）的活性。正常血压和高血压（由于饮食中添加 8.0%氯化钠）的 DS 大鼠心肌组织中的毒蕈碱受体浓度较低，ChAT 和 AChE 活性也低于正常血压的 DR 大鼠。DS 品系心肌中较低的受体位点密度和酶活性可能反映了迷走神经张力的降低。如果属实，这可能会导致在血压（BP）升高时适当调节心率（HR）的能力出现缺陷。因此，目前的结果可被视为 DS 品系高血压发病机制中的加重因素。