人类高血压患者血清和尿液中N-乙酰-β-D-氨基葡萄糖苷酶活性增加：肾功能障碍的早期指标。

Increased serum and urinary N-acetyl-beta-D-glucosaminidase activity in human hypertension: early indicator of renal dysfunction.

作者信息

Simon G, Morioka S, Snyder D K

出版信息

Clin Exp Hypertens A. 1984;6(4):879-96. doi: 10.3109/10641968409044044.

DOI:10.3109/10641968409044044

Abstract

The pathophysiologic significance of increased serum and urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in hypertension was investigated. The subjects were 32 male patients, aged 40-65 years, with mild or borderline, uncomplicated hypertension and 26 age-matched, male normotensive volunteers. Compared to values in control subjects, NAG activity in the serum, spot and 24-hour urine samples of hypertensive subjects was increased (p less than 0.01). Serum NAG activity in hypertensive subjects was inversely correlated with glomerular filtration rate (r = -0.49, p less than 0.01, N = 31) and renal plasma flow (r = -0.56, p less than 0.02, N = 19) and positively correlated with mean arterial blood pressure (r = 0.40, p less than 0.05). The elevation of serum NAG activity in hypertension is a biochemical marker of the reduction in glomerular filtration rate and renal plasma flow.

摘要

研究了高血压患者血清和尿液中N - 乙酰 - β - D - 氨基葡萄糖苷酶（NAG）活性升高的病理生理意义。研究对象为32名年龄在40 - 65岁之间的男性患者，患有轻度或临界、未并发的高血压，以及26名年龄匹配的男性血压正常志愿者。与对照组相比，高血压患者血清、即时尿样和24小时尿样中的NAG活性升高（p < 0.01）。高血压患者的血清NAG活性与肾小球滤过率呈负相关（r = -0.49，p < 0.01，N = 31），与肾血浆流量呈负相关（r = -0.56，p < 0.02，N = 19），与平均动脉血压呈正相关（r = 0.40，p < 0.05）。高血压患者血清NAG活性升高是肾小球滤过率和肾血浆流量降低的生化标志物。