García M, Méndez X, Botey A, Pons J M, Revert L
Med Clin (Barc). 1981 Sep 25;77(5):200-4.
Essential arterial hypertension, malignant hypertension and renovascular hypertension were studied in 64 patients, divided into 5 groups according to creatinine clearance (Ccreat) and ophthalmic fundus. Urine N-Acetyl-b-d-glucosaminidase (NAG) was expressed in units/mg creatinine in urine. Results were; Group A: Ccreat greater than 60, ophthalmic fundus less than II (n=33), NAG 13.5 + 4.5; Group B: CCreat. greater than 60, ophthalmic fundus III-IV (n=4) NAG 42.4 +/- 12.5; Group C: Ccreat. less than 60, ophthalmic fundus less than II (n = 14) NAG 31.2 +/- 10,5; Group D: (clinically malignant arterial hypertension) Ccreat. less than 60, ophthalmic fundus III--IV (n = 8), NAG 91.1 +/- 55.7 and Group E: (renovascular hypertension) Ccreat. greater than 60, ophthalmic fundus less than II (n = 5), NAG 35.5 +/- 12.9. Only the patients in Group A had NAG within normal limits. Differences were found between groups: A-B (p less than 0.001), A-D (p less than 0.001), A-E (p less than 0.001) and C-D (p less than 0.001). Urine NAG is considered to be an early sign of renal involvement in arterial hypertension, an indication of the severity and a sign of ischemia even when the involvement is unilateral only, and helpful in the management of renovascular hypertension.
对64例患者进行了原发性动脉高血压、恶性高血压和肾血管性高血压的研究，根据肌酐清除率（Ccreat）和眼底情况将其分为5组。尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）以每毫克尿肌酐中的单位数表示。结果如下：A组：Ccreat大于60，眼底低于II级（n = 33），NAG为13.5±4.5；B组：Ccreat大于60，眼底III - IV级（n = 4），NAG为42.4±12.5；C组：Ccreat小于60，眼底低于II级（n = 14），NAG为31.2±10.5；D组：（临床恶性动脉高血压）Ccreat小于60，眼底III - IV级（n = 8），NAG为91.1±55.7；E组：（肾血管性高血压）Ccreat大于60，眼底低于II级（n = 5），NAG为35.5±12.9。只有A组患者的NAG在正常范围内。各分组之间存在差异：A - B（p小于0.001），A - D（p小于0.001），A - E（p小于0.001）和C - D（p小于0.001）。尿NAG被认为是动脉高血压肾脏受累的早期迹象，是严重程度的指标，即使仅为单侧受累也是缺血的迹象，并且有助于肾血管性高血压的管理。
