Goldstein P
Cytobios. 1984;39(154):101-8.
Two sterile mutants of Caenorhabditis elegans hermaphrodites have been examined using the electron microscope and serial section analysis. The F4 and F80 mutants were described previously ( Mounier and Brun , 1980), and they were shown to be blocked at the start of oogenesis. In the F4 mutant, normal sperm are produced and the pachytene nuclei contain tripartite synaptonemal complexes (SC) between the homologously paired chromosomes. In the F80 asynaptic mutant, only a few sperm are produced and they have abnormal morphology. Whereas SCs and SC associated structures (termed 'SC knobs') are present in the F4, these structures are absent from the F80 . The mutation in F80 affects gametogenesis prior to the pachytene stage of meiosis and pairing of homologous chromosomes apparently does not occur. The SC knobs may influence the regulation of the disjunction of the chromosomes. For that reason, these structures are now termed 'disjunction regulator regions'.
利用电子显微镜和连续切片分析，对秀丽隐杆线虫雌雄同体的两个不育突变体进行了研究。F4和F80突变体先前已有描述（穆尼耶和平，1980年），研究表明它们在卵子发生开始时受阻。在F4突变体中，能产生正常精子，粗线期细胞核在同源配对染色体之间含有三联体联会复合体（SC）。在F80非联会突变体中，只产生少数精子，且精子形态异常。虽然F4中存在SC和与SC相关的结构（称为“SC节”），但F80中没有这些结构。F80中的突变在减数分裂粗线期之前影响配子发生，同源染色体的配对显然不会发生。SC节可能影响染色体分离的调控。因此，现在将这些结构称为“分离调节区”。
