Goldstein P
Chromosoma. 1986;93(3):256-60. doi: 10.1007/BF00292746.
The dominant X-autosome heterozygous translocation mutant mnT6 of the nematode Caenorhabditis elegans has an X chromosome that has been reduced in size by 40%, yet the remainder of the bivalent pairs effectively at pachytene and has a synaptonemal complex (SC) that has a normal appearance. Six SCs are present in pachytene nuclei of this mutant which correspond to a haploid value of n = 6. Nondisjunction of the X chromosome occurs at a rate of 37% and there are no 'Disjunction Regulator Regions' (DRR) in this him (high incidence of males) mutant. This is consistent with the notion that DRRs either promote disjunction or inhibit nondisjunction of the X chromosome. Their occurrence in pachytene nuclei is independent of the mechanism responsible for nondisjunction, i.e. point mutations as in him-8 versus chromosomal aberrations as in mnT6. Although an SC is present along the entire length of the X chromosome, crossover suppression is observed in mnT6.
线虫秀丽隐杆线虫的显性X-常染色体杂合易位突变体mnT6的X染色体大小减少了40%，然而在粗线期二价体对的其余部分有效，并且具有外观正常的联会复合体（SC）。该突变体的粗线期细胞核中有六个SC，对应单倍体值n = 6。X染色体的不分离发生率为37%，并且在这个雄性高发生率（him）突变体中没有“分离调节区域”（DRR）。这与DRR要么促进X染色体分离要么抑制其不分离的观点一致。它们在粗线期细胞核中的出现与负责不分离的机制无关，即与him-8中的点突变相比，mnT6中的染色体畸变。尽管沿着X染色体的整个长度都存在SC，但在mnT6中观察到了交叉抑制。
