Raininko R
Eur J Radiol. 1984 Feb;4(1):14-8.
Immediate morphological alterations in the vascular endothelium were studied in the common iliac artery and muscle capillaries of the rat after perfusions ranging from 3 to 120 seconds. Isotonic meglumine diatrizoate and saline produced no perceptible changes. Hypertonic solutions produced cell shrinkage and deformation of the intercellular spaces of the iliac artery in all cases. Shrinkage of the endothelial cells was also accompanied by shrinkage of the neighbouring cells. Hypertonic solutions did not always produce alterations in the capillaries; the frequency of such alterations was greater with saline. It is suggested that meglumine diatrizoate causes circulatory disturbance which affects its distribution to the microvasculature.
在对大鼠髂总动脉和肌肉毛细血管进行3至120秒的灌注后，研究了血管内皮的即时形态学改变。等渗的泛影葡胺和生理盐水未产生明显变化。在所有情况下，高渗溶液均导致髂动脉细胞收缩和细胞间隙变形。内皮细胞的收缩还伴随着相邻细胞的收缩。高渗溶液并不总是引起毛细血管的改变；生理盐水引起这种改变的频率更高。提示泛影葡胺会导致循环障碍，从而影响其在微血管中的分布。
