Raininko R
Angiology. 1981 Nov;32(11):733-41. doi: 10.1177/000331978103201101.
Ultrastructural changes in vascular endothelium after an intra-aortic injection of 65% meglumine diatrizoate, 10 ml/kg, and equiosmolal hypertonic saline were observed using electron microscopy in the rat. Cell shrinkage and expansion of intercellular clefts were found in all specimens from a large artery at 5 and 20 minutes after injection. Some destroyed cells were seen at all times after contrast and hypertonic saline administration, but one-half of the specimens taken at 1 hour were otherwise nearly normal in appearance. In muscle capillaries, the changes were less severe than in the large artery. Despite the large dose, equiosmolal meglumine diatrizoate and saline solutions produced identical vascular lesions as detected with electron microscopy.
在大鼠体内，通过电子显微镜观察了经主动脉注射10ml/kg 65%泛影葡胺和等渗高渗盐水后血管内皮的超微结构变化。注射后5分钟和20分钟，在大动脉的所有标本中均发现细胞皱缩和细胞间隙增宽。在注射造影剂和高渗盐水后的各个时间点均可见到一些受损细胞，但在1小时时采集的标本中，有一半外观几乎正常。在肌毛细血管中，变化程度比大动脉轻。尽管剂量很大，但电子显微镜检测显示，等渗泛影葡胺溶液和盐溶液产生的血管损伤相同。
