Hirai F, Aoyama H, Ohtoshi M, Kawashima S, Ozawa K, Tobe T
Eur Surg Res. 1984;16(3):148-55. doi: 10.1159/000128402.
Liver mitochondrial phosphorylative activity, hepatic adenine nucleotides, and hemodynamic parameters were studied in 23 pigs with peritonitis induced by cecal ligation and perforation. Between 2 and 7 days after treatment, the onset of an apparent hyperdynamic state, characterized by an increased cardiac index and decreased total peripheral resistance index, occurred. In this period, the energy charge level was barely maintained and the occurrence of liver mitochondrial enhancement was observed. However, 10-14 days after treatment, the onset of a hypodynamic state with its inverse patterns in hemodynamics took place. In this period, the energy charge level fell to 0.68, concomitant with a marked decrease in mitochondrial function. Further, a high positive correlation between the cardiac index and liver mitochondrial phosphorylative activity was noted (r = 0.85, p less than 0.01). These results suggest that liver mitochondria play a major role in the metabolic and hemodynamic adaptations occurring during sepsis.
对23只通过盲肠结扎和穿孔诱导腹膜炎的猪进行了肝脏线粒体磷酸化活性、肝脏腺嘌呤核苷酸和血流动力学参数的研究。在治疗后2至7天之间，出现了明显的高动力状态，其特征为心脏指数增加和总外周阻力指数降低。在此期间，能量电荷水平勉强维持，并观察到肝脏线粒体增强的发生。然而，治疗后10 - 14天，出现了低动力状态，其血流动力学模式相反。在此期间，能量电荷水平降至0.68，同时线粒体功能显著下降。此外，观察到心脏指数与肝脏线粒体磷酸化活性之间存在高度正相关（r = 0.85，p小于0.01）。这些结果表明，肝脏线粒体在脓毒症期间发生的代谢和血流动力学适应中起主要作用。
