己双肾上腺素对离体大鼠壁细胞摄取14C-氨基比林的增强作用。
Potentiating action of hexoprenaline on 14C-aminopyrine uptake by isolated rat parietal cells.
作者信息
Maśliński S, Ruoff H J
出版信息
Experientia. 1984 May 15;40(5):478-80. doi: 10.1007/BF01952394.
PMID:6723912
Abstract
Hexoprenaline potentiated the 14C-aminopyrine uptake (a reliable index of H+ generation) of isolated rat gastric cells stimulated by 10(-6) -10(-4) mol/l carbachol, and inhibited that in response to 10(-4) mol/l histamine without and in the presence of propranolol. It is concluded that hexoprenaline acts as a partial agonist on parietal cell H2-receptors and that beta-adrenoceptor activation may functionally modulate gastric acid secretion.
摘要
己酮可可碱增强了由10⁻⁶ - 10⁻⁴mol/L卡巴胆碱刺激的离体大鼠胃细胞对¹⁴C-氨基比林的摄取（氢离子生成的可靠指标），并在有无普萘洛尔存在的情况下，抑制了对10⁻⁴mol/L组胺的反应。得出的结论是，己酮可可碱作为壁细胞H₂受体的部分激动剂起作用，并且β-肾上腺素能受体激活可能在功能上调节胃酸分泌。
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