Watanabe T, Nagura H, Watanabe K, Brown W R
FEBS Lett. 1984 Mar 26;168(2):203-7. doi: 10.1016/0014-5793(84)80246-x.
It was recognized that in human milk some amounts of lactoferrin (LF) were naturally bound to secretory IgA (sIgA). Since not only secretory component (SC) but also LF was released from sIgA by disulfide bond cleavage, it is conceivable that LF is naturally bound to IgA as well as SC. An in vitro binding test to LF and IgA was performed and the binding was confirmed by the use of an IgA-Sepharose 4B affinity column.
人们认识到，在人乳中，一定量的乳铁蛋白（LF）天然地与分泌型IgA（sIgA）结合。由于不仅分泌成分（SC），而且LF都可通过二硫键断裂从sIgA中释放出来，因此可以推测LF与IgA以及SC天然结合。进行了LF与IgA的体外结合试验，并通过使用IgA-琼脂糖4B亲和柱证实了这种结合。
