Savarino V, Mansi C, Pugliese V, Ferrara G B, Arcuri V, Celle G
Digestion. 1984;29(1):1-4. doi: 10.1159/000199000.
This study was carried out to assess the diagnostic accuracy of a new gastrointestinal cancer antigen ( GICA ) defined by a monoclonal antibody. Its sensitivity and specificity were assayed in a group of patients with different pancreatic diseases (10 acute pancreatitis, 27 chronic pancreatitis, 22 cancers of the pancreas) and in 29 normal individuals. The concentration of GICA was always inferior to 37 units/ml (our discriminant limit between cancer and noncancer patients) both in cases with chronic pancreatitis and in healthy subjects. Increased levels of the antigen were found in 16/22 (72.7%) pancreatic cancer patients and in 3/10 (33.3%) cases with acute pancreatitis. The assay was within the normal range in 2 (28.6%) out of 7 cancers judged resectable. The test is simple and rapid, but its relative sensitivity and the frequent elevation of GICA in other adenocarcinomas of the gastrointestinal tract make it unsuitable for screening programs in pancreatic cancer. Even its use for early diagnosis of cancer of the pancreas does not seem promising. The major finding of our study is the lack of false-positives in patients with chronic pancreatitis and therefore the usefulness of this test in differentiating preoperatively between chronic inflammation and cancer of the gland. Frequent increase of the marker in patients with acute pancreatitis is not yet clear.
本研究旨在评估一种由单克隆抗体定义的新型胃肠道癌抗原（GICA）的诊断准确性。在一组患有不同胰腺疾病的患者（10例急性胰腺炎、27例慢性胰腺炎、22例胰腺癌）以及29名正常个体中检测了其敏感性和特异性。在慢性胰腺炎患者和健康受试者中，GICA浓度始终低于37单位/毫升（我们区分癌症患者和非癌症患者的判别界限）。在22例胰腺癌患者中有16例（72.7%）以及10例急性胰腺炎患者中有3例（33.3%）发现抗原水平升高。在7例判断为可切除的癌症中，有2例（28.6%）检测结果在正常范围内。该检测方法简单快速，但其相对敏感性以及在其他胃肠道腺癌中GICA频繁升高的情况使其不适用于胰腺癌的筛查项目。甚至其用于胰腺癌早期诊断似乎也没有前景。我们研究的主要发现是慢性胰腺炎患者中没有假阳性结果，因此该检测在术前区分腺体的慢性炎症和癌症方面有用。急性胰腺炎患者中该标志物频繁升高的原因尚不清楚。
