van Buul-Offers S
Growth. 1984 Spring;48(1):101-19.
A dose-dependent increase in body length and weight can be induced in Snell dwarf mice by human, porcine and bovine growth hormones, ovine prolactin, bovine TSH, T4 and T3, and to a lesser extent by insulin. In contrast, porcine FSH, equine LH, testosterone, oestradiol and glucagon influenced neither body length nor weight. Beside body length and weight, the weight of many organs is stimulated by hormonal treatment. GH, T4 and T3 have a rather similar spectrum of effects, with exceptions for the skinfold and epididymal fat-pads. LH had no effect, but in contrast FSH had a strong effect on the seminal vesicles and a less pronounced one on the testis. Oestradiol induced a marked enlargement of the uterus, whereas testosterone increased the weights of the kidneys and seminal vesicles. The main action of insulin is probably localized on body fat. Glucagon, however, did not stimulate organ growth. These data illustrate again the complexity of hormonal regulation of growth.
人、猪和牛生长激素、羊催乳素、牛促甲状腺激素、T4和T3可使斯内尔侏儒小鼠的体长和体重呈剂量依赖性增加，胰岛素的作用较小。相比之下，猪促卵泡素、马促黄体生成素、睾酮、雌二醇和胰高血糖素对体长和体重均无影响。除体长和体重外，激素处理还会刺激许多器官的重量增加。生长激素、T4和T3的作用谱相当相似，但对皮肤褶皱和附睾脂肪垫的作用除外。促黄体生成素没有作用，但相比之下，促卵泡素对精囊有强烈作用，对睾丸的作用则不太明显。雌二醇使子宫明显增大，而睾酮则增加了肾脏和精囊的重量。胰岛素的主要作用可能集中在身体脂肪上。然而，胰高血糖素不会刺激器官生长。这些数据再次说明了生长激素调节的复杂性。
