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人体网膜组织的脂质组成与生物合成

Lipid composition and biosynthesis of human omental tissue.

作者信息

Rabinowitz J I, Askins S E, Luddy F E

出版信息

Lipids. 1978 May;13(5):317-22. doi: 10.1007/BF02533721.

DOI:10.1007/BF02533721
PMID:672467
Abstract

Two groups of five males each were selected for total lipid analyses of their omental tissue. One of these groups had been subjected to a severe caloric restriction and had undergone total weight reduction of about 20%. The other group served as control. Both of these groups of patients required elective surgical procedures during which it was possible to obtain small samples of omental tissue, adipose pad, and/or mesenteric tissue. Total lipid analyses were performed on all of the materials. A distinctive positional distribution of the acyl groups was maintained in the triglycerides of omental tissue for all the patients regardless of dietary state. Patients under caloric restriction showed a reduction in their total triglyceride content, a reduction in their content of unsaturated fatty acyl groups, and a relative increase in phospholipid content. The de novo lipid biosynthetic capacity of omental tissues, as determined by 1-[14C]-acetate incorporation, showed an inverse proportionality to the lipid content of the samples. Omental tissue is biosynthetically a very versatile material capable of yielding rapidly many types of fatty acids. This ability, among others, could account for the usefulness of omental tissue as a supporting base in many types of restorative surgery.

摘要

选择两组男性,每组五人,对他们的网膜组织进行总脂质分析。其中一组经历了严格的热量限制,体重总共减轻了约20%。另一组作为对照。这两组患者都需要进行择期外科手术,在此过程中有可能获取少量网膜组织、脂肪垫和/或肠系膜组织样本。对所有这些材料都进行了总脂质分析。无论饮食状态如何,所有患者网膜组织甘油三酯中酰基都保持着独特的位置分布。热量限制下的患者总甘油三酯含量降低,不饱和脂肪酰基含量降低,磷脂含量相对增加。通过1-[14C]-乙酸掺入法测定,网膜组织从头脂质生物合成能力与样本脂质含量呈反比。网膜组织在生物合成方面是一种非常通用的材料,能够快速产生多种类型的脂肪酸。这种能力以及其他能力可以解释网膜组织在许多类型的修复手术中作为支撑基础的有用性。

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引用本文的文献

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2
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