Rao G A, Siler K, Larkin E C
Lipids. 1978 May;13(5):356-9. doi: 10.1007/BF02533728.
Male Sprague-Dawley rats were fed for 8 weeks a corn oil (CO) diet or a hydrogenated coconut oil (HCNO) diet. These diets were fed in the absence or presence of eicosa-5,8,11,14-tetraynoic acid (TYA). The inclusion of TYA in the HCNO diet reduced the levels of 12:0 and 14:0 in the total fatty acids of livers and plasma. With either diet, the presence of TYA caused an alteration in the fatty acid composition of these tissues so as to reduce the values of the ratios: 16:1/16:0, 18:1/18:0. and 20:4/18:2. These results suggest that dietary TYA can influence the hepatic metabolism of medium chain fatty acids and that it may inhibit the desaturase enzyme involved in the synthesis of not only 20:4 but also of monoenoic fatty acids.
将雄性斯普拉格-道利大鼠用玉米油（CO）饮食或氢化椰子油（HCNO）饮食喂养8周。这些饮食在有无二十碳-5,8,11,14-四炔酸（TYA）的情况下喂养。在HCNO饮食中加入TYA可降低肝脏和血浆总脂肪酸中12:0和14:0的水平。无论采用哪种饮食，TYA的存在都会导致这些组织的脂肪酸组成发生变化，从而降低以下比率的值：16:1/16:0、18:1/18:0和20:4/18:2。这些结果表明，膳食TYA可影响中链脂肪酸的肝脏代谢，并且它可能抑制不仅参与20:4合成而且参与单不饱和脂肪酸合成的去饱和酶。
